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Title Metabolomics investigation to shed light on cheese as a possible piece in the French paradox puzzle.
Authors Zheng H, Yde CC, Clausen MR, Kristensen M, Lorenzen J, Astrup A, Bertram HC
Source Journal of agricultural and food chemistry
Date of publication 2015 Mar 18
Volume 63
Issue 10
Pages 2830-9
Abstract An NMR-based metabolomics approach was used to investigate the differentiation between subjects consuming cheese or milk and to elucidate the potential link to an effect on blood cholesterol level. Fifteen healthy young men participated in a full crossover study during which they consumed three isocaloric diets with similar fat contents that were either (i) high in milk, (ii) high in cheese with equal amounts of dairy calcium, or (iii) a control diet for 14 days. Urine and feces samples were collected and analyzed by NMR-based metabolomics. Cheese and milk consumption decreased urinary choline and TMAO levels and increased fecal excretion of acetate, propionate, and lipid. Compared with milk intake, cheese consumption significantly reduced urinary citrate, creatine, and creatinine levels and significantly increased the microbiota-related metabolites butyrate, hippurate, and malonate. Correlation analyses indicated that microbial and lipid metabolism could be involved in the dairy-induced effects on blood cholesterol level.
Medical Subject Headings (MeSH)
Adolescent ; Cattle ; * Cheese [analysis];  Cheese [utilization] ; * Cholesterol [blood] ; Cross-Over Studies ; Metabolomics ; * Milk [metabolism]

Mesh check words: • Adult • Animals • Humans • Male • Middle Aged • Young Adult

Language eng
Accession Number PUBMED 25727903
DOI 10.1021/jf505878a
Publication type Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
ID CN-01110341
Available Links PubMed