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Title Dairy Consumption Lowers Systemic Inflammation and Liver Enzymes in Typically Low-Dairy Consumers with Clinical Characteristics of Metabolic Syndrome.
Authors Dugan CE, Aguilar D, Park Y-K, Lee J-Y, Fernandez ML
Source Journal of the American College of Nutrition
Date of publication 2016
Volume 35
Issue 3
Pages 255-61
Abstract Objectives: A 6-week cross-over study design was used to determine the effect of increased dairy consumption in typically low-dairy consumers (n = 37) with metabolic syndrome (MetS) on systemic inflammation and hepatic enzymes. Methods: This was a randomized study in which participants consumed low-fat dairy (LFD) (10 oz 1% milk, 6 oz nonfat yogurt, 4 oz 2% cheese) or a carbohydrate-based control (CNT) (1.5 oz granola bar and 12 oz 100% juice) for 6 weeks. After a 4-week washout, they were allocated to the alternate dietary treatment. Inflammatory status was assessed by fasting plasma concentrations of C-reactive protein (CRP), tumor necrosis factor alpha (TNF-alpha), and monocyte chemoattractant -1 (MCP-1). In addition, gene expression of interleukin (IL)-1, IL-6, and TNF-alpha was evaluated in peripheral blood mononuclear cells isolated from a subset of 17 subjects (13 women, 3 men) at the end of each dietary period. Liver enzymes were also assessed to evaluate whether dairy components would affect hepatic function. Results: Participants had lower concentrations of both hepatic alanine aminotransferase (p < 0.05) and aspartate aminotransferase (p < 0.005) after the LFD period. No significant changes in any of the plasma inflammatory compounds were found when all data were analyzed together. In contrast, expression of IL-1b and IL-6 were reduced by 46% and 63%, respectively, compared to the control period. When stratified by gender, women had lower TNF-alpha, (p = 0.028) and MCP-1 (p = 0.001) following LFD consumption compared to CNT. In addition, hepatic steatosis index scores were significantly lower (p < 0.001) during the LFD period. Conclusions: We conclude that three dairy servings per day improved both liver function and systemic inflammation in subjects with MetS.
EMBASE keywords
article // controlled study // crossover procedure // *dairy product // dietary intake // fatty liver // female // *food intake // gene expression // human // *inflammation // liver function // low fat diet // male // metabolic syndrome X // milk // peripheral blood mononuclear cell // randomized controlled trial // RNA analysis // RNA extraction // alanine aminotransferase/ec [Endogenous Compound] // aspartate aminotransferase/ec [Endogenous Compound] // C reactive protein/ec [Endogenous Compound] // interleukin 1/ec [Endogenous Compound] // interleukin 6/ec [Endogenous Compound] // *liver enzyme/ec [Endogenous Compound] // monocyte chemotactic protein 1/ec [Endogenous Compound] // tumor necrosis factor alpha/ec [Endogenous Compound] // yoghurt
Publisher name Routledge
City of publication United States
Correspondence address M.L. Fernandez, Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269-1110, United States. E-mail: maria-luz.fernandez@uconn.edu
Language eng
Accession Number EMBASE 2015536711
DOI http://dx.doi.org/10.1080/07315724.2015.1022637
Publication type Journal: Article
ID CN-01140732